Industrial scale-up of countercurrent chromatography: predictive scale-up.

Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10-20 mg) purification by using hydroxyapatite and 2) large scale (tested up to 140 mg) purification by high-performance countercurrent chromatography (HPCCC).

Mathematical modelling of an annular photocatalytic reactor for methylene blue degradation under UV light irradiation using rGO-ZnO hybrid

The application of heterogeneous photocatalysis in industrial scale has been hindered by a lack of simple mathematical models that can be easily applied to reactor design and scale-up. This work intends to use a simple mathematical model for predicting methylene blue (MB) degradation in a slurry-annular photocatalytic reactor using zinc oxide (ZnO) hybridized with reduced graphene oxide (rGO)-Z...

Scale-up Strategies for Membrane-Based Desalination Processes: A Review

Membrane-based technologies have increasingly been chosen in desalination processes, which is evidenced by the increase of large-scale plants constructed in recent years. Indeed, several appropriate strategies should be considered to minimize problems faced during the construction, such as membrane system designs, area requirement, energy requirement, operation and maintenance, and environmenta...

Experimental Demonstration of the Thermochemical Reduction of Ceria in a Solar Aerosol Reactor

We report on the experimental demonstration of an aerosol solar reactor for the thermal reduction of ceria, as part of a thermochemical redox cycle for splitting H2O and CO2. The concept utilizes a cavity-receiver enclosing an array of alumina tubes, each containing a downward gravity-driven aerosol flow of ceria particles countercurrent to an inert sweep gas flow for intrinsic separation of re...

Production Scale Up of Nanofibers: A Review